A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease
title:
A Randomized, Double-Blind, Phase 3 Study to Investigate the Efficacy and Safety of LY3437943 Once Weekly Compared to Placebo in Participants With Severe Obesity and Established Cardiovascular Disease
medical condition:
Obesity | Cardiovascular Disease
age:
18+
sex/gender:
All
Overview
The main purpose of this study is to evaluate the efficacy and safety of retatrutide once weekly in participants with obesity and established cardiovascular disease (CVD). The study will last about 113 weeks.
Study Details
Inclusion Criteria:
Have a body mass index (BMI) ≥35.0 kilogram/square meter (kg/m²).
Have established cardiovascular (CV) disease with at least 1 of the following:
prior myocardial infarction
prior ischemic or hemorrhagic stroke, or
symptomatic peripheral arterial disease
Have a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight.
Exclusion Criteria:
Have had acute myocardial infarction, stroke, coronary revascularization, hospitalization for unstable angina, or hospitalization due to congestive heart failure within 90 days prior to screening.
Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening.
Have a prior or planned surgical treatment of obesity.
Have a change in body weight greater than 5 kg (11 pounds) within 90 days prior to screening.
Have Type 1 diabetes.
Have family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
